The PrenatalSAFE Test

PrenatalSAFE® is a non-invasive prenatal test which analyses free circulating fetal DNA isolated from a maternal blood sample to provides 6 levels of detailed and a complete information of a pregnancy. The test allows the detection of aneuploidies and microdeletion syndromes, from the most common to the rarest, structural alterations in all the chromosomes of the fetus and the presence of mutations related to serious genetic diseases. 

PrenatalSAFE® is offered by the Eurofins Genoma Group laboratories with an option to choose from six levels of prenatal screening, each with a different level of detail.



                                                              is the most technologically advanced non-invasive prenatal test currently available 

By analyzing the free fetal DNA (cfDNA) circulating in the mother's blood, this new non-invasive prenatal test is able to screen fetal karyotype and serious genetic diseases in the fetus. PrenatalSAFE® Complete in its "Plus" version also detects the 9 most common microdeletion syndromes.

 


Detects aneuploidy and structural chromosomal alterations (segmental deletions and duplications) of each chromosome. Moreover, it allows identifying the 9 most common microdeletion syndromes in the fetus under PrenatalSAFE® Karyo Plus screening. 

Micro-deletion Chromosomal Region Prevalance
DiGeorge Synodrome Deletion 22q11.2 1/4,000
Cri du Chat Syndrome Deletion 5p15.3 1/20,000 - 1/50,000
Prader-Willi Syndrome Deletion 15q11.2 1/10,000 - 1/25,000
Angelman Syndrome Deletion 15q11.2 1/12,000
Deletion 1p36 Syndrome Deletion 1p36 1/4,000 - 1/10,000
Wolf-Hirschhorn Syndrome Deletion 4p16.3 1/50,000
Jacobsen Syndrome Deletion 11q23 1/100,000
Langer-Giedion Syndrome Deletion 8q24 1/200,000
Smith-Magenis Syndrome Deletion 17p11.2 1/15,000 - 1/25,000

 



Screens the aneuploidies of chromosomes 21, 18, 13,  and the trisomy of chromosomes 9 and 16. The test also detects the presence of the 6 most common microdeletion syndromes.

 

Micro-deletion Chromosomal Region Prevalance
DiGeorge Synodrome Deletion 22q11.2 1/4,000
Cri du Chat Syndrome Deletion 5p15.3 1/20,000 - 1/50,000
Prader-Willi Syndrome Deletion 15q11.2 1/10,000 - 1/25,000
Angelman Syndrome Deletion 15q11.2 1/12,000 
Deletion 1p36 Syndrome Deletion 1p36 1/4,000 - 1/10,000
Wolf-Hirschhorn Syndrome Deletion 4p16.3 1/50,000

 

 

Detects the aneuploidies of chromosomes 21, 18, 13, sex chromosomes (X and Y), and includes the determination of fetal sex (optional). 

 


 Evaluates the aneuploidies of chromosomes 21, 18, 13, and includes the determination of fetal sex (optional). 

 

PrenatalSAFE® can be combined with the RhSafe® test, a non-invasive prenatal examination that, by analysing fetal DNA isolated from a blood sample of the pregnant woman, allows to determine the Fetal Rh(D) factor. The RhSafe® test is optional and is performed on request in case of Rh(D) negative pregnant women with Rh(D) positive partner.